Our laboratory conducts Mathematical Modeling and Computation (MMC) which builds mathematical models for simulating physical and chemical problems and solves them by supercomputers. Interdisciplinary studies among physics, chemistry and biology are desirable for expanding an innovative study. MMC is one of the interdisciplinary studies. Particularly, we now explore Multiphysics CFD (MCFD) as a research field of MMC expanded from Computational Fluid Dynamics (CFD). CFD solves Navier-Stokes equations (NS) as a mathematical model. MCFD solves additional mathematical models governing physical and chemical problems with NS.  Currently, we promote two research projects. One develops Numerical Turbine that achieves large-scale computations of moist-air and wet-steam flows in full-annulus gas and steam turbines. Another is Supercritical-fluids Simulator　(SFS) that realizes the simulation of complex flows with arbitrary substances such as water, carbon dioxide, and hydrocarbon in gas, liquid, and supercritical-fluid states with the phase change. Furthermore, AI technology is being applied to NT for creating a digital twin of gas turbine only by the simulation database (SDB).